Mutation Screening
Ensure that a causative mutation carried by any of your family member doesn’t pass on to generations to come!
A5 DNA Lab offers a cutting-edge mutation detection service for extended family screening and union of two people, providing valuable insights for informed decision-making. Our experts utilize advanced molecular techniques, such as PCR and Sanger sequencing, to screen for a known causative mutation in all members of a family for knowing about their carrier status. Our comprehensive service includes DNA extraction, PCR amplification, sequencing, and analysis, followed by counselling and interpretation of results. By detecting mutations, individuals and families make informed decisions about their health and reproductive choices, mitigating the risk of passing on inherited diseases to future generations. At A5 DNA Lab, we prioritize accuracy, confidentiality, and compassionate support, empowering individuals and families to take proactive steps towards a healthier future.
PRICE
Varies between 20 $ (5000 PKR) to 100 $ (25000 PKR), depending on number of individuals and type of the mutation detection technique.
Frequently Asked Questions
Mutations can result from errors in DNA replication during cell division, exposure to mutagens or a viral infection. Germline mutations (that occur in eggs and sperm) can be passed on to offspring, while somatic mutations (that occur in body cells) are not passed on.
All exploit one or more of the basic properties of DNA or the enzymes that act upon it. Single base pair mutations can easily be identified by direct sequencing, which involves identifying each individual base pair, in sequence, and comparing the sequence to that of the normal gene.
Some mutations have a positive effect on the organism in which they occur. They are called beneficial mutations. They lead to new versions of proteins that help organisms adapt to changes in their environment. Beneficial mutations are essential for evolution to occur.
PCR generates an amplicon that is then analyzed by some other method to find possible variations within the amplicon. PCR based methods only detect mutations that have been previously identified by some other techniques if now sequencing step is added.
The main difference between mutation and variation is that mutation is an alteration in the nucleotide sequence of a gene whereas variation is any difference between individuals of a particular species.
A mutation is a change in the DNA that is rare and associated with a change in phenotype from wild type. A polymorphism is more common and typically not associated with a change in phenotype.
